Here's the kicker: there IS a left-handed option for those of you who want to hold your Wii Remote in your left hands. The way IGN describes this feature was a bit confusing since they start off by saying "Link can be left-handed," but they seem to clarify it won't change Link's appearance on-screen. Suffice to say that if you select this option, the game will calibrate the Wii Motion Plus with the fact that you're playing with the opposite arm in mind.
I've wondered a bit whether we'll be starting the actual game with six hearts, and IGN seems to confirm it here. The counterbalance to this? Typical enemies take off a full heart when they damage you. Say goodbye, three-heart runs! You shall be missed.
Source: Zelda Informer